Yeah that can be a problem. Basically, you want to get the fastest stable combination of FSB speed and memory speed. FSB speed (i.e. CPU speed) is always more important.
So for example let's say your CPU can do 275Mhz FSB, but your memory can only do 420Mhz. You could either go with 262Mhz FSB and 420Mhz memory, or 275Mhz FSB and 367 Mhz memory. The 275 Mhz FSB will almost certainly provide a faster system (because it means an extra 150Mhz for a 2.4C, more for a 2.6 or a 2.8), even though the memory is somewhat slower.
Here's a table of FSB vs memory speeds for 1:1, 5:4, and 3:2. It should give you some idea of when you would need to jump from one ratio to another.
FSB 1:1 5:4 3:2
200 400 320 266.8
205 410 328 273.47
210 420 336 280.14
215 430 344 286.81
220 440 352 293.48
225 450 360 300.15
230 460 368 306.82
235 470 376 313.49
240 480 384 320.16
245 490 392 326.83
250 500 400 333.5
255 510 408 340.17
260 520 416 346.84
265 530 424 353.51
270 540 432 360.18
275 550 440 366.85
280 560 448 373.52
285 570 456 380.19
290 580 464 386.86
295 590 472 393.53
300 600 480 400.2