Personally I don't think that it would really give you any benefit at all. The fan is going to suck all the dust into your case off of the floor, so you would have to put an air filter on it. Also, there won't be much room between the bottom of the case and your floor, so the fan won't be pushing much air anyways, then the air filter will cut it down to close to nothing unless you install a obnoxious loud fan there. It's certaintly possible, but I wouldn't do it.