I use Norton AV 03 Pro, it works great..I have it turned off when I do'nt need it using up 78% of my resources.
I scan an ocasional program here and there..and sometimes when I go to bed scan everything.
I tried 04, but the activation, and all of the security features were a pain (hate to be anyone who tried stealing it..).
So I just use 03 pro instead.
They all use the same definitions, so it doesn't matter..
As for registry and spyware..I use Adaware 6 I think..works great..
and for temp files and registry I use System Mechanic..a wonderful program.