Will memory timings ever be a bottleneck?

As long as faster (more efficient) CPU's, better video cards, and higher FSB speeds are availible will CAS Latency ever be a big bottleneck in performance?
I'm asking because I've always ran my memory at pretty tight timings, but I just upgraded to a gig of memory and it wont run with very tight timings (it runs at 2.5-3-3-11) so I'm paranoid about it.

The cost of going from 2-2-2-11 to 2.5-3-3-11 on and nForce2 board is ~2 to 2.5% at ~200 FSB. That translates directly into FSB speed, for example a 200 FSB using 2-2-2-11 and a 204-205 FSB at 2.5-3-3-11 should be equal in performance. This is different than numbers associated with older memory and boards based on VIA KT333 chipset you'll hear quoted.

Tight timings are becoming less important than they used to be, assuming you don't go to timings like 4-5-5-11.