Stumped

[Seanohue]

Ok I have tried every anti-virus, anti-spy out there and nothing will fix my pop-ups. AVG doesnt pick up anything, HiJackThis! didnt even find anything malicious. Pop-up stopper and Secretmaker don't block anything, and I have pop-ups coming from IE and Firefox. What else is there to try?

[HaTE]

try this http://www.trendmicro.com/cwshredder/

[Seanohue]

picked up nothing :bang head

[Schalldampfer]

Did you try Webroot?

[habbajabba]

My prob is that I hate it when I have to reload a page in IE just to download something. IE sucks the big one. I only use it with a proxy. Even if I tell it to not block popups it still blocks every single download & if they are exe's, every single one will be preceded by MS's weakass "do you want to run..." BS. If it weren't for the fact that sp2 is faster I would go back to sp1 just to get rid of this annoying crap.
Sounds to me like you have absolutely no control over your pc. You should download process explorer & when you get a popup drag the icon to the window of the popup & it will be highlited in the tsk mgr pane. Then just search for the offending file, whatever it may be & delete it. Just pray that it is not explorer. Sounds like a sp1 issue. System internals also have a real time reg monitor as well as a real time file monitor among others
http://www.sysinternals.com/ProcessesAndThreadsUtilities.html

[Seanohue]

This is odd lol. When I have the reg monitor open, I see no pop-ups. When I close it, BOOM! pop-up. Is there any explanation to this?

[Seanohue]

nvrmnd, must not hav had any at that time. they are back :( anyone got any ideas?

[habbajabba]

Use your OS cd for REPAIR or just do a clean install ??

[ZhengHe]

Use your OS cd for REPAIR or just do a clean install ??

Agreed, you probably have some really horrible spyware in there that really wouldn't be worth trying to clean out. Save some important files to Gmail, ShinyFeet, or something along those lines and then do a clean reinstall of your OS, then scan those files before you load them back in. Also, spyware stopping programs, along with antivirus, firewall, registry repair, and anything else security related usually won't do you much good to install if you're already infected with spyware or viruses. Research your programs, install them early and yes, for many programs the payed option is the best one, and then do regular scans for each and of course practice safe surfing habits. Unfortunately for your the problem is likely beyond repair but in the future the best way to guard against these things is to prevent them and if you need help with reinstall most of us here could help you out.