I use 1/2" barbs on everything. Of course, the barbs are always different. In my up and coming loop, my CPU, GPU and Res will have Swiftech High-Flow 1/2" barbs (G1/4" thread), my Thermochill Rad has similar barbs, and my pump has standard 1/2" plastic barbs. I'm going to be using 7/16" MasterKleer tubing. It's cheaper, easier to route, puts less torque on blocks (possibly less chances on leaks if I screw up). I don't use clamps when I use 7/16" tubing, it is very snug and I've never had any leaks (only time I've ever had leaks was when I was using 1/2"x3/4" Clearflex60 and didn't tighten the clamps down enough). That said, using clamps can't hurt at all. I use standard $.60 worm drive clamps from home depot, but the best clamps out there are smooth-band worm-drive clamps. QuietIce explained them prior to my post.