Folding wat does it mean??

[packratbob]

errrr i hear heaps of people talking abt it! wat does this actually mean??
am i the only one that doesnt know lol

help neone??

[Bobnifty]

yah what is it
is it like a seti thing?

[res0r9lm]

nah it's way better than seti. it's helping to find cures for diseases

The purpose of the project is to discover how proteins fold and how they misfold. When a protein creates itself it does so through a process known as folding. It takes just fractions of a second for the protein to be created, however there are numerous steps that take place during the process and there are things that can go wrong during the creation of the protein causing it to misfold. Misfolded proteins are thought to be responsible for many of the more difficult to cure diseases that people are afflicted with every day. This project is concentrating on the Alzheimers proteins and how they fold and misfold, but models are being created that should allow for future research in all areas of medicine. Finding out how proteins fold and misfold requires that we break down the steps of the entire folding process and then recreate the process. Though the process takes very little time it is very complicated. Analyses of the folding of even the simplest of proteins requires significant super computing power, and more complex analyses has been impossible until recently. The amount of computing power required to perform these calculations and to come up with any worthwhile results is massive and most supercomputers today would buckle under the pressure. This is where we come into the picture with Folding@Home.

We are part of a diverse team (Team 32) made up of people from all over the world, with experience ranging from the extreme computer enthusiast to the computer novice, that have come together to pool our resources for the benefit of finding out how proteins fold and misfold. By using the Folding@Home software on our computers we are able to provide our idle cpu cycles for the benefit of this research. Chances are that you are, on average, only using about 10% of the power that is provided by your ultra fast Pentium and Athlon cpus. That means that 90% of the time that your PC is powered up your processor is doing absolutely nothing. By running the Folding@Home software on your PC you can effectively use 100% of the processors capability, and since it only uses computing cycles that are idle(unused) it should not interfere with the normal operation of your computer. You should not even notice that it is running. The Folding@Home client will download a small amount of work from the Stanford University computers and it will then use the idle cycles on your computer to perform the calculations on that small amount of work before sending it back and asking for more. The work units, as they are called, take a long time to complete even on the fastest home computers. Some work may take hours and some work may take days. You may even think that nothing is happening but your computer will be busy, running in the background, working on the problems of misfolded proteins.

[peppy]

Folding, is folding at home is basically using 100% of your computer to help cure altzheimers. i think its cooler than seti cause it helps us humans:)

http://folding.stanford.edu/

http://www.overclockers.ws

Beat me to the punch res0r9lm :D , well u have a better response anyways

ps: i fold:cool:

[Bobnifty]

wow
i'm quitin seti
so the 32 team is just like the overclockers team for seti
and i can join right?

[packratbob]

so help me help u!!!! lol how do i get in to folding, i love helping pples

[CrystalMethod]

This topic belongs in "General Computer Related Discussion", please try and post in the proper section of the forums next time.

[Yodums]

You guys should be crunching. ET needs you.

You guys need to use CPU Processor to find ET, as well as explore the universe, explore into astronomy with stars etc :D

http://www.ocsetiteam.com/

Yodums

[res0r9lm]

hey the more the merrier. just download the client from one of the link peppy post and make sure to use 32 as the team #

[res0r9lm]

Originally posted by CrystalMethod
This topic belongs in "General Computer Related Discussion", please try and post in the proper section of the forums next time.
actually I think it belongs in the folding forum. by the way there are no aliens. except for the ones with green cards

[funnyperson1]

Originally posted by res0r9lm

actually I think it belongs in the folding forum. by the way there are no aliens. except for the ones with green cards

or without them:D

"Strong with the fold this boy is, fold you must, hmmm?"

[NedClocker]

Originally posted by res0r9lm

actually I think it belongs in the folding forum. by the way there are no aliens. except for the ones with green cards
Yeah, what's wrong with it being in folding?

[masitti]

Ahh, now I know what folding is. I am gonna go and sign up now...

[Edward2]

After you get started, you should add your system to the "How much have we got folding?" thread. Team 32 currently has over 500 GHz and is working towards 750 GHz. Here is the link:

http://forum.oc-forums.com/vb/showthread.php?s=&postid=773608#post773608

[NASsoccer]

Originally posted by msmasitti
Ahh, now I know what folding is. I am gonna go and sign up now...

glad to here of you great choice:) also make sure you get in the contest and see if you can get yourself a duron!!!!!

[packratbob]

Sorri folks and mods. i didnt know there was a folding section till i posted this thanks for all the help neways i just kept reading that ppl were folding and i had no idea but now i know and am happy folding with my two rigs

Sorri again mods. anyways it gives a chance for all the cooling nuts to find out wat it is.
like me :):D :) :D

[parkan]

You should all be crunching for distributed.net (I know I am going to be mecilessly flamed for this)

And a small correction, a protein does not create itself, it is formed by a ribosome matching the anticondons of mRNA to codons of tRNA and connecting the aminoacids attached to mRNA together. (I might have switched mRNA and tRNA around, sorry)

[res0r9lm]

and another small correction it is protein:p

[Crash893]

"You should all be crunching for distributed.net (I know I am going to be mecilessly flamed for this)"

just out of curoisity why do you think we should work for them?

i always thought we should go freelance
have a company pay us for are cpu time

[NASsoccer]

Originally posted by parkan
You should all be crunching for distributed.net (I know I am going to be mecilessly flamed for this)


yeah why is that??


ps- we dont flame:)

[David]

Originally posted by parkan
And a small correction, a portein does not create itself, it is formed by a ribosome matching the anticondons of mRNA to codons of tRNA and connecting the aminoacids attached to mRNA together. (I might have switched mRNA and tRNA around, sorry)

mRNA is transcribed from DNA and has many codons (3 base pairs) which each code for a specific amino acid.
The mRNA then exits the nucleus and pairs up with a ribosome, either in the cytoplasm or in the Rough Endoplasmic Reticulum. tRNA molecules (possessing an anticodon, which is the oposite of a codon. Eg, if the mRNA codon is AGU then the tRNA anticodon is UCA) carry an amino acid each. The amino acid they carry depends on the anticodon. The codons and anticodons pair up and the amino acids join via peptide bonds to form molecules called polypeptides.

This is where folding comes in. The process of protein folding gives molecules their shape, which is vital to their function. Especially globular and conjugated proteins. If an amino acid is wrong (through some mutation) then the protein may not fold correctly and the protein will be ineffective.

Haemoglobin, when it misfolds is less effective at carrying Oxygen and becomes sickle shaped. This gives rise to Sickle Cell Anaemia and Sickle Cell Trait. Another inborn error of metabolism is Phenylketonuria which, due to an ineffectiv misfolded enzyme, cannot convert Phenylalanine to Tyrosine effectively. Thus Phenylalanine builds up in the persons body and may potentially be converted to toxic substances.

I knew Biology would be useful someday... :rolleyes:

David

[Mr B]

[Wilford Brimly voice] "Folding...it's the right thing to do."[/Wilford Brimly voice]

:D

[Matthew1001]

Obviously Cooling isn't the right section but why have the mods not moved it to Folding@Home or GD?

[NedClocker]

Originally posted by Matthew1001
Obviously Cooling isn't the right section but why have the mods not moved it to Folding@Home or GD?
sssssssssssssssssssssh. leave well enough alone (please???)
it relates to cooling.

[masitti]

For advertising of course. I know I would have NEVER looked into the Folding@Home section; thanks to packratbob, I know we have easily gained 5-10 people folding now (including me!); just by asking a simple question here. I thought this was something complicated; it really isn't, and this helped out.

[NedClocker]

Originally posted by crash893
i always thought we should go freelance
have a company pay us for are cpu time
If you find one that will, please let me know!!! :D

[res0r9lm]

folding will definitly need good cooling.

[masitti]

Originally posted by res0r9lm
folding will definitly need good cooling.

Couldn't agree with you more. I don't mind my CPU temps being at 61c for a few days; esp. since I know I am getting new components. But I wouldn't let it run like this all the time.

[packratbob]

c it does have to do with cooling after all lol. hey while folding i still have temps of 32 max thats great. Seems the more load i give it the more my water block likes. seem i can.t heat it up over the 32 deg mark. unless i turn the fans of or pump off of course lol

Folding is great!! help fold for oc.
i didnt know wat was folding b4 this post but i think is good to use ur spare cpu usage to help do something productive.

hmm maybe the mods leaving it here cos it has something to do with cooling. lol

[masitti]

LOL, I have caught the watercooling bug. :eh?:

;)

[gtsimmo]

Our folding members are haveing a contest/lottery and we're giving out free hardware, so check out our section of the forum. New members even get their own bonus contest too.

[parkan]

Originally posted by David


mRNA is transcribed from DNA and has many codons (3 base pairs) which each code for a specific amino acid.
The mRNA then exits the nucleus and pairs up with a ribosome, either in the cytoplasm or in the Rough Endoplasmic Reticulum. tRNA molecules (possessing an anticodon, which is the oposite of a codon. Eg, if the mRNA codon is AGU then the tRNA anticodon is UCA) carry an amino acid each. The amino acid they carry depends on the anticodon. The codons and anticodons pair up and the amino acids join via peptide bonds to form molecules called polypeptides.

This is where folding comes in. The process of protein folding gives molecules their shape, which is vital to their function. Especially globular and conjugated proteins. If an amino acid is wrong (through some mutation) then the protein may not fold correctly and the protein will be ineffective.

Haemoglobin, when it misfolds is less effective at carrying Oxygen and becomes sickle shaped. This gives rise to Sickle Cell Anaemia and Sickle Cell Trait. Another inborn error of metabolism is Phenylketonuria which, due to an ineffectiv misfolded enzyme, cannot convert Phenylalanine to Tyrosine effectively. Thus Phenylalanine builds up in the persons body and may potentially be converted to toxic substances.

I knew Biology would be useful someday... :rolleyes:

David

Yes,I did switch mRNA and tRNA... whoops :eek:

[Penguin4x4]

Originally posted by res0r9lm
nah it's way better than seti. it's helping to find cures for diseases

The purpose of the project is to discover how proteins fold and how they misfold. When a protein creates itself it does so through a process known as folding. It takes just fractions of a second for the protein to be created, however there are numerous steps that take place during the process and there are things that can go wrong during the creation of the protein causing it to misfold. Misfolded proteins are thought to be responsible for many of the more difficult to cure diseases that people are afflicted with every day. This project is concentrating on the Alzheimers proteins and how they fold and misfold, but models are being created that should allow for future research in all areas of medicine. Finding out how proteins fold and misfold requires that we break down the steps of the entire folding process and then recreate the process. Though the process takes very little time it is very complicated. Analyses of the folding of even the simplest of proteins requires significant super computing power, and more complex analyses has been impossible until recently. The amount of computing power required to perform these calculations and to come up with any worthwhile results is massive and most supercomputers today would buckle under the pressure. This is where we come into the picture with Folding@Home.

We are part of a diverse team (Team 32) made up of people from all over the world, with experience ranging from the extreme computer enthusiast to the computer novice, that have come together to pool our resources for the benefit of finding out how proteins fold and misfold. By using the Folding@Home software on our computers we are able to provide our idle cpu cycles for the benefit of this research. Chances are that you are, on average, only using about 10% of the power that is provided by your ultra fast Pentium and Athlon cpus. That means that 90% of the time that your PC is powered up your processor is doing absolutely nothing. By running the Folding@Home software on your PC you can effectively use 100% of the processors capability, and since it only uses computing cycles that are idle(unused) it should not interfere with the normal operation of your computer. You should not even notice that it is running. The Folding@Home client will download a small amount of work from the Stanford University computers and it will then use the idle cycles on your computer to perform the calculations on that small amount of work before sending it back and asking for more. The work units, as they are called, take a long time to complete even on the fastest home computers. Some work may take hours and some work may take days. You may even think that nothing is happening but your computer will be busy, running in the background, working on the problems of misfolded proteins.
Really? Wonder why I haven't heard of this before, :cry:, my cousin just went through leukemia chemo.

KICK ASS!!!!!!!!!!!!!:) :) :)
________
Chrysler rb engine history (http://www.dodge-wiki.com/wiki/Chrysler_RB_engine)

[ed8150]

hmm it seems that we just need to get out and contact people, many are more than willing to do it once they know. the only problem is how to communicate what the point is, how little is required of the person, in a format they they can look over quickly(ie banner ad)

[army_man]

well u guys just talked a salesman into goin with it. add another 2Ghz to ur goal cuz i am in. great stuff

[gtsimmo]

Welcome to the team, and if you got any question post them up in the folding section.

[packratbob]

Originally posted by gtsimmo
Welcome to the team, and if you got any question post them up in the folding section.
okie

[Wedo]

Welcome to the Folding team all that joined. I think we should get our hands on a water cooling set up for the prize in our next contest. A cold folding rig is a happy folding rig.

[/shameless plug] :D

Wedo

[army_man]

yes it is. my puter been at 50c since i started.

[gtsimmo]

That's hot, but Intel CPUs are pretty though. I would work on your cooling army_man. My Volcano 7+ keeps my Duron CPU nice and cool at 36 to 37 deg at full load.

[NedClocker]

Originally posted by gtsimmo
That's hot, but Intel CPUs are pretty though. I would work on your cooling army_man. My Volcano 7+ keeps my Duron CPU nice and cool at 36 to 37 deg at full load.
Are you serious? That's darned good.

[res0r9lm]

Originally posted by NedClocker

Are you serious? That's darned good.

I think he is referring to army_man's 50c

[NedClocker]

Originally posted by res0r9lm


I think he is referring to army_man's 50c

"My Volcano 7+ keeps my Duron CPU nice and cool at 36 to 37 deg at full load. "

[res0r9lm]

Originally posted by NedClocker


"My Volcano 7+ keeps my Duron CPU nice and cool at 36 to 37 deg at full load. "

ok, you lost me for second.

[gtsimmo]

Yup that's right folks, well the weather here is heating up a bit lately, damn california heat. So it went up two degress so it's now at 39 deg with folding running. At night or in cooler temperature it drops to as low as 34 deg

[jamesvbon]

my 2 rigs are now up and folding adding another 2.9 total ghz to the pool thnx guys

[Luie]

There's a contest going on in Folding. You can have a chance to win a Duron!!!

Click on the link in my sig.(signature) to sign up.

[packratbob]

I've been folding for 3 days straight with my sig and my temps havent gone over 33 degc ever.

[Luie]

I've been folding for 3 days straight with my sig and my temps havent gone over 33 degc ever.

I wish I have better cooling like yours....
My temp goes around 55C when folding @ 145fsb +0.1Vcore.
Temp are around 48C when folding @ 140fsb -0.025Vcore.

I hope I would make a trip to a computer store in the weekends...
btw, does Fry's sell AX-7 yet?
Last time I saw, the best was the MCX-### (forgot the numbers.)

[craigiz1]

If you crunch for SETI and help find ET, he...it...they will possibly bring the cures for our diseases. :D

[Luie]

If you crunch for SETI and help find ET, he...it...they will possibly bring the cures for our diseases.

There's also a risk for us that the ETs might take over our planet and put us all to slaves.:eek: :D lol

For folding proteins, there is no risk!:D ;)

(I'm a folder myself) lol

[NedClocker]

Originally posted by craigiz1
If you crunch for SETI and help find ET, he...it...they will possibly bring the cures for our diseases. :D
Look at our history. What usually happens when a more advanced civilization meets a less advanced civilization?

[Luie]

Look at our history. What usually happens when a more advanced civilization meets a less advanced civilization?


Where can we see it? I think I would be quite interesting.

[NedClocker]

Originally posted by luie



Where can we see it? I think I would be quite interesting.
History books. Maybe HistoryChannel.com
One example would be when the Spaniards invaded South America, took the gold and killed the natives.

[NedClocker]

Or, when the white man decided he wanted North America and practically eliminated the Native Americas.

[Luie]

History books. Maybe HistoryChannel.com
One example would be when the Spaniards invaded South America, took the gold and killed the natives.

Oh, icic.
Yep, I know what you're saying.
I was very tired when I posted my last post. =P