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Install one card and the drivers, re-boot and install the other card and the drivers again. Re-boot. You'll have no issue.
looking at your mobo's specs I dont see it as either sli or xfire capable. you have one pci-e 3.0 slot and 1 pci-e 2.0 (x4) slots just cause it has 2 slots does not mean its capable of offering sli or xfire.
I'd go 290x, one with a good cooler.
You could even add a second one down the line as your mobo is crossfire compatible...
Asus’ original P8Z77-V LX was, and still is, a solid entry-level Z77 motherboard. Can the P8Z77-V LX2 motherboard’s subtle design changes and reduced price prove that it is ready to compete in the tough sub-£80 Z77 motherboard market?