Ill tell ya what it is!
Ok, what this is is what is being said, but only partialy, the drive is making a sort of 'list' of whats on the drive. In Win2k and I beleive 9X the program is called FindFast.exe (very annoying and worthless I might add) and what it does is looks over the drive every now and then to see what is there, it helps make things go faster. such as opening programs or when searching for files. As for XP, well its already a bloated operating system so I wouldnt be surprised, as for the name of the program? beats me. As far as different drives areconcerned, its more of chance. sometimes the program gets disabled and you dont even know it.
The second thing is if your HDD is formatted NTFS and you right click on a fiule/folder and select properties. there will be an "advanced" button, there will be a election for "cache/register this folder for faster search times" or something like that...just gotta dig around. If you dont mind it, then dont worry about it
Hope this helps ya'll out or something
*Edit* that NTFS thing only works on NTx or later (obviously)
*Edit*Also, a drive doing this doesnt mean its going bad, going to melt, is being hacked/copied/formated/erased/etc its just another way for M$ to annoy you. your HDD being hacked would be a steady light (like when copying files) and a drive dying would be a nice clicking sound (or something similar). anyways...peace out yo!