Probably Genome. My grandfather had one of those, exact same speed, and it was an absolute dog. It might be able to handle some Tinker cores, but I don't know about the real big ones. Definately less powerful than a PII of the same clock speed. No SSE on these so Gromacs are probably not even worth considering.
They don't overclock all that well, for the most part. They run extremely hot, but I'd get what I can from it...you're going to need it.