Stormer, it'd depend on the chipset you're using. It would have to be a Linux supported chipset to run a RAID in, most likely a Promise chipset.
I don't do RAID but I do use the Serial ATA on my K8V SE Deluxe and I use the sata_promise kernel module.
I think Gentoo has a ATA-RAID howto in their user documentation for installing Gentoo on a RAID, not sure what you'd do for a different distro though.