I differ with all of you, and I have a 'little' bit of experience with this subject...
Jigsaw for Plexi.. NO.....
Slow speed...NO
Special Discs...NO
Straight lines, you can use a standard issue utility knife, score it at least 4 times (hard)... Then carefully bend it, and it will snap to a nice clean line, of course this all depends on the thickness of the plexi, thick stuff I would score BOTH sides....
Cutting shapes, YOU CAN use a Dremel, there are just certain ways of going about it so that it works right, and it takes practice to get it right...
FIRST.... You will use a cutting wheel, the standard wheel work fine, but you can get the more expensive reinforced ones, as they will last longer..
SECOND.. Crank it up full speed!!!
THIRD.... DO NOT use the wheel like you would a circular saw!!!!!!!!!
FOURTH..... Makes small cuts, the width of the blade (about 1 inch), DON"T PUSH!!! let the wheel do the work, make sure you have saftey goggles, as the high speed actually pulls the plastic off and shoots it away from the plexi..... YOU WILL make a cut when through, lift wheel entirely out or cut, move over to start next cut where the end of previous cut is..... continue till entire cut is done...... That is for straight lines, any residual plastic pieces that are stuck to plexi, will snap right off when hard, THEY WILL NOT MELT BACK TO the plexi, as some people say (if this is done correctly).. then you can switch to a fine grit sanding drum on LOW speed to clean up the cut if need be.. This process also does not chew up discs as fast....
NOW for a round cut...... same deal, small cuts only,fast speed... except this time you will hold the cutting wheel INSIDE the round, so the round of the wheel follows the round of your cut, the wheel should be approx 45 degrees to the plexi, and make your cut yes it will leave a beveled edge but that will be cleaned up later, it is near impossible to make a round cut holding the wheel at 90 degrees to the plexi, it can be done, BUT it doesn't look very good, and it takes a lot of work to clean it up........
NOW for smaller 'round' cuts, I hope you saved all the cutting wheels that you ground down, the small wheels come in handy ofr intricate cuts, follow the same directions....
Oh and by the Way, I would reccommed DURPLEX brand plexi/acrylic, you can smack it with a hammer and it won't shatter!
I hope everyone here learned something.................