I'd say it can be very safe as long as you are careful, take your time during assembly, and for leaks regularly. With my 600 GPH, 10.2 foot head, Eheim 1260 I checked for leaks actively for about 2 hours then daily for a week or so, bumping to weekly, then monthly to whenever I get bored or suspect a problem now. With my metal barbs and steel belt clamps I'm almost completely certain a tube can't blow off and I've got the tubing routed with large "U"'s ensuring that any fluid from a slow leak will be directed away from my motherboard and graphics card.
Has it leaked? Yes twice, once after a couple hours and once after a month.
The first time I was using a plastic resovior. I didn't have a clamp on the pump's output barb thinking the tubings elasticity would hold it on. Yeah, lol I was wrong. I was leaning back in my chair when the pipe let loose and the pump blew the lid off the res. It scared me so bad I fell back in my chair and took my head off a book self. I saw stars. Dove under the desk and yanked the cord out of the wall instinctively and was stunned for a couple seconds when the fountain and computer continued to run. Forgot about the UPS.
Anyways the the computer was fine as the res it outside of the computer case and the carpet was green when it was bought to it turned out fine. Fixed that problem so it'll never happen again.
The second time was only a seep. The tubing directed it safely to the floor away from the electronics and was found probably with in a day or so. Probably only lost a cup or so and thats just a dent in the 2 gallon res.
Nothing damaged and it's been running for about 8 months+ now 24/7 with no worries.
Higher quality water and antifreeze will reduce the chance of shorting somehthing out in event of a leak, but if there is dust in the box for it to mix with this safeguard is circumvented. Either way you'll still want good water to keep corrosion and organisms down in your system. I've heard good things and bad things about fluidXP and never tried it.
Bottem line, if you want to watercool check and recheck. A little planning can help out in the long run. Low pressure and low quantity setups will probably end up being the safest but anything can be worked to run for long term safely.