tRCD & tRP are usually equal numbers between 2 and 4. In tweaking for more overclockability, lower tRP first between these two
CAS should be either 2.0 or 2.5. Many systems, most nforce2, fail to boot with a 3.0 setting or have stability problems. CAS is not most critical of the various timings, unlike what is taught by many. In general, the importance of CAS when placed against tRP and tRCD is nominal. Reducing CAS has a relatively minor effect on memory performance, while lower tRP & tRCD values result in a much more substantial gain. In other words if you had to choose, 3-3-2.5 would be better than 4-4-2.0 (tRCD-tRP-CAS)
tRAS should always be larger the before mentioned timings. – see below
tRAS is unique, in that lowering it can lead to problems and lesser performance. tRAS is the only timing that has no effect on real performance, if it is configured as it should. By definition, real-life performance is the same with different tRAS settings with a certain exception. This document from Mushkin outlines how tRAS should be a sum of tRCD, CAS, and 2. For example, if you are using a tRCD of 2 and a CAS of 2 on your RAM, then you should set tRAS to 6. At values lower than that theory would dictate lesser performance as well as catastrophic consequences for data integrity including hard drive addressing schemes --- truncation, data corruption, etc --- as a cycle or process would be ended before it's done. How is it possible for memory timings to affect my hard drive? When the system is shut down or a program is closed, physical ram data that becomes corrupted may be written back to the hard drive and that’s where the consequences for the hard drive come in. Also let’s not forget when physical ram data is translated by the operating system to virtual memory space located on the hard drive.
While it's important to consider the advice of experts like Mushkin, your own testing is still valuable. Systems – both AMD & Intel alike, can indeed operate with stability with 2-2-2-5 timings, and even exhibit a performance gain as compared to the theoretically mandated 2-2-2-6 configuration. The most important thing in any endeavor is to keep an open mind, and don't spare the effort. Once you've tried both approaches extensively it will be clear to you which is superior for your particular combination of components.