Consider a good heatpipe cooler, the more pipes the better. I'm running ninjas on all my Big horses and none of them reach more than the lower 40s in this summer heat.
Keeping it below 60 improves longevity and the lower the better. It's always possible that temps above 50 could cause crashes due to hot spots that can exceed 70C but never detected in the thermal diode(s). Consider heat patterns to be similar to what you see in brain activity scans on an MRI. One part can heat up above the detected temp due to the fact that part is not close to the diode(s). The temps are detected for the total effect of the chip and is located near the hotest point determined by the engineers. This is the technical reason why we run all these superpi's, prime95, cpuburn, 3D Mark etc just to use as much of the proc as possible. Running the chip cooler allows faster heat dissapation and limits these hotspots from reaching higher than spec.