You'll have to run that RAM w/ a RAM multiplier to use it at those speeds. When your FSB is set to 333 (1333 effective) your RAM will be running at 667 if you run it 1:1. You'll have to run your RAM 1:2 to get it up to 1333, and doing this has been shown to have negligible effects on performance. I would be curious as to how tight you can get the timings if you underclock that DDR3 1333 to 667 speeds, though. It looks like you have the impression that the rated FSB of a chip is supposed to match the rated speed of the RAM. This is incorrect. To actually run 1:1 the rated FSB should be twice that of the rated speed of the RAM. You only need DDR2-533 RAM to run a 1066FSB, and DDR2-667 RAM to run a 1333FSB at 1:1. DDR3-1333 requires a rated FSB speed of 2666 to run 1:1!
*note: Rated FSB is the quad-pumped (4x) actual FSB. Rated RAM speed is the dual-channel (2x) of the actual FSB.
If you could get your actual FSB up to 667, then you could run your RAM 1:1 at its rated speed. That is easier said than done, though. You're going to need an exceptional chip, LN2, and a lot of luck to get to 667, and I don't think you can stay there very long.
DDR3 just hasn't shown that it's any better than DDR2 yet. I know the speeds look impressive, but the latencies negate the speed benefit.
IMHO if you're looking to spend uber cash then I think you could spend it elsewhere and get better performance. Wait a couple weeks, and get the X38 (DDR2 version). As for CPU...x3230, or QX6850 maybe? Don't forget a top-of-the-line GPU either.