Overclockers

Cluster · 12-22-08, 12:06 AM

Normally when we talk milestones, its someone crossing off they're next million points, but this is a milestone that no folding farm by itself could ever hope to live up to. This is a F@H Milestone for EVERYONE...

Vijay's Blog

Quote:

Originally Posted by Dr. Vijay Pande

This is very preliminary news, but something I'm very, very excited about, so I'll give some advance news. On Tuesday, we presented our results regarding new possible drugs (small molecule leads) to fight Alzheimer's Disease at a recent meeting at Stanford. This meeting was part of the NIH Roadmap Nanomedicine center (http://proteinfoldingcenter.org/) retreat and was supported by NIH grants to Folding@home.
It's very early (so we are not publicly talking about the details until this has passed peer review), but we are very excited that it looks like we may have multiple small molecules which appear to inhibit toxicity of Abeta, the protein which is the toxic element in Alzheimer's Disease.

This is exciting in many ways. It's been a long road for FAH to get to this point, but we are starting to see the possibility of seeing these results published easily before our 10th birthday (October 2010). Considering all the technology development that had to be done in the first five years, these results have come very quickly (in the last 3 years), which is exciting. In particular, we are now looking to apply these methods to other protein misfolding diseases (we have pilot projects for Huntington's Disease underway).

Finally, I should stress that while we're very excited about this, it's still early and a lot can go wrong between where we are and having a drug that doctors can prescribe. Over the holidays, we will be double checking the experimental data, crossing t's and dotting i's to make sure there is nothing missed before we think about submitting this for peer reviewed publication. Also, there is still a long way from an interesting possible drug (where we are now) to something which has passed FDA clinical trials (where we'd love to be), and a lot can go wrong in clinical trials in particular.

Thus, this is an important milestone for FAH and we are very grateful to all who have contributed. Happy holidays to all!

I think this is a very monumental step for the project, as Vijay points out, it has been a long road, over 8 years in the making. This is a great thing in my eyes, about a year ago i lost my grandmother to alzhiemers, and this disease is not something i would wish on anybody. I wish the pande group much success with their research into this.

ihrsetrdr · 12-22-08, 12:26 AM

Thanks for posting this up, Cluster...news such as this is what keeps our dedicated folding rigs folding.

Burninate35 · 12-22-08, 01:34 AM

This is great.
This could also get the skeptics on board. you know the people who say that it is just a waste of power.

Shun the non believer Shunnnnnnnnnnn

orion456 · 12-22-08, 03:15 AM

Adds a nice touch of hope at Christmas.

Merry Christmas to all!

MARCI · 12-22-08, 03:34 AM

beers all around.

dfonda · 12-22-08, 07:12 AM

Pretty good reason to Fold.

Thanks for posting cluster.

drshivas · 12-22-08, 09:59 PM

Thanks for sharing Cluster. This kind of promising news, regardless if it's valid or not in the end, is very important to me as it keeps me folding- and justifying the electricity, time and hardware expenses.

Along these lines, I want to share a post I started in the Other Teams subforum regarding the Rosetta@home BOINC folding project, to which I also donate:

http://www.ocforums.com/showthread.php?t=587762

I feel long term, projects such as these will ultimately benefit mankind, and that's why I stay in the fold.

jintatsu · 12-23-08, 06:08 AM

Is_907 · 12-23-08, 09:07 AM

I'm really glad to see this. When I first heard about folding five years ago I don't think I imagined having results like this--preliminary though they are--so soon.

Great news!

sbinh · 12-23-08, 03:36 PM

Quote:

Originally Posted by MARCI

beers all around.

Coffee please . i don't drink beers lol

ihrsetrdr · 12-23-08, 04:59 PM

Quote:

Originally Posted by sbinh

Coffee please . i don't drink beers lol

I don't drink beer either, usually just:

Go ahead and have one, or grab yourself some

drshivas · 12-23-08, 06:29 PM

+1 for seltzer/club soda! That stuff keeps me from drinking soda all the time!

Cluster · 12-24-08, 08:11 PM

I'll take a tequila thanks, oh and hold the fruit and pass the salt!

12-22-08, 12:26 AM	#2
ihrsetrdr Senior Member Join Date: May 2005 Location: 71 miles N.E. up the freeway from Newegg- Main Office.	Thanks for posting this up, Cluster...news such as this is what keeps our dedicated folding rigs folding. __________________ Team 32 Folding Mentor- go ahead and ask me! "You're only given a little spark of madness. You mustn't lose it.” -- Robin Williams Heat

12-22-08, 03:15 AM	#4
orion456 Join Date: May 2004 Location: Canada	Adds a nice touch of hope at Christmas. Merry Christmas to all! __________________ -- W3570 @ 3.8 P6TD on Swiftech H20-220 -- QX9650 P5K-E on Swiftech H20-220 water, ATI 3870, G.Skill PC 8500. The only thing for sure, is that nothing is for sure!

12-22-08, 03:34 AM	#5
MARCI Join Date: Jun 2008 Location: Folding for T32 in Lawrenceville, Ga	beers all around. __________________ My Heat C2D E8400 @3.6 1.184vCore GIGABYTE EP45-DS3L 8 GB G.SKILL PC8500 MSI GTX260 (216) OC 896MB folding 24/7 CORSAIR CMPSU-1000HX

12-22-08, 07:12 AM	#6
dfonda Senior Member Join Date: Feb 2004 Location: Folding for Team 32 in PA, 45 miles North of Splat.	Pretty good reason to Fold. Thanks for posting cluster. __________________ #1Win764GPUFolding260GTX(On Rosie) I7 920@3.2GHZ #2Win764GPU2FoldingQ6600Rosie9800GX2 & 9800GTX+ #3WinXP(Asleep for the summer)E6600 GPU2(2x8800GT) Folding for Hrstrder's wife, Pete_Scout(PS3) and Oldskool

12-22-08, 09:59 PM	#7
drshivas Sith Lord Join Date: Jun 2003 Location: Maryland, USA	Thanks for sharing Cluster. This kind of promising news, regardless if it's valid or not in the end, is very important to me as it keeps me folding- and justifying the electricity, time and hardware expenses. Along these lines, I want to share a post I started in the Other Teams subforum regarding the Rosetta@home BOINC folding project, to which I also donate: http://www.ocforums.com/showthread.php?t=587762 I feel long term, projects such as these will ultimately benefit mankind, and that's why I stay in the fold. __________________ ·Folding for the OCF Rosetta@Home & T32 Folding@Home Teams ·Q9550 @3.6GHz (8.5x425)\|·ASUS P5Q-Pro\|·9600 GT GPU2 + Folding Rosetta@home ·Q9550 @3.4GHz (8.5x400)\|·GA-EP35-DS3R\|·6200 LE Folding Rosetta@home ·Q9450 @3.4GHz (8x425)\|·GA-P35-DS3R\|·8400 GS (G98) Folding Rosetta@home ·E6320 @2.8GHz (7x400)\|·ASUS P5B-E\|·8400 GS (G98) Folding Rosetta@home GET FOLDING! Help Find a Cure for various diseases -- Join the OCF Rosetta Team!-- Here's why... \| Heatware

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12-22-08, 01:34 AM	#3
Burninate35 Member Join Date: Oct 2008	This is great. This could also get the skeptics on board. you know the people who say that it is just a waste of power. Shun the non believer Shunnnnnnnnnnn

12-23-08, 06:08 AM	#8
jintatsu Join Date: Oct 2007 Location: Folding@Philippines	__________________ Intel C2Q Q9550 @ 2.8Ghz (1.1v) \| Thermalright Ultra 120 Extreme \| GSkill 2x2Gb ddr2-1066 Gigabyte GA-P35-DS3P v1.1 \| Thermalright HR-05 IFX \| MSI 8800GTS 512MB Corsair HX620 \| Cooler Master CM690 \| Creative Sound Blaster X-Fi Xtrememusic Fold for [Team 32] Use your idle computer to fold

12-23-08, 09:07 AM	#9
Is_907 Join Date: May 2002 Location: Roanoke, TX	I'm really glad to see this. When I first heard about folding five years ago I don't think I imagined having results like this--preliminary though they are--so soon. Great news! __________________ Desktop Rig - Q6600 @ 2.8GHz; Xigmatek HDT-S1283; 8GB G.skill; 320GB WD; PNY GeForce 9800GT 512MB; Windows 7 (7000) x64. Fold for Team 32

12-23-08, 06:29 PM	#12
drshivas Sith Lord Join Date: Jun 2003 Location: Maryland, USA	+1 for seltzer/club soda! That stuff keeps me from drinking soda all the time! __________________ ·Folding for the OCF Rosetta@Home & T32 Folding@Home Teams ·Q9550 @3.6GHz (8.5x425)\|·ASUS P5Q-Pro\|·9600 GT GPU2 + Folding Rosetta@home ·Q9550 @3.4GHz (8.5x400)\|·GA-EP35-DS3R\|·6200 LE Folding Rosetta@home ·Q9450 @3.4GHz (8x425)\|·GA-P35-DS3R\|·8400 GS (G98) Folding Rosetta@home ·E6320 @2.8GHz (7x400)\|·ASUS P5B-E\|·8400 GS (G98) Folding Rosetta@home GET FOLDING! Help Find a Cure for various diseases -- Join the OCF Rosetta Team!-- Here's why... \| Heatware

12-24-08, 08:11 PM	#13
Cluster Join Date: Dec 2001 Location: Canuckistan	I'll take a tequila thanks, oh and hold the fruit and pass the salt! __________________ Multi VM/SMP Folding Guide \| Ram Timing Guide \| Folding working on Alzheimer's cure GPU Countdown to new years - Fold for a cure! Asus M3A79-T ~ Phenom 9850 ~ Cell Shock DDR-1066 ~ HIS HD4850 Phenom 9850 Rank : PiFast (1st) \| wPrime32 (1st) \| wPrime1024 (1st) \| SPi1M (1st) \| SPi32M (2nd)