If you take out the top fan, and are willing to cut the top aluminum a bit, a dual radiator fits perfectly there. The plastic cover can still go there slightly unmodified, if you put 4 fans on the rad, you have to cut a little bit out, but it can be made to look nice. That's where I put mine, I had to cut some of the tray part on the top, but it still looks fine.
Other than that, you can put a pump under the HD cages, and easily get 2.5TB of space, if you get bigger drives. I have 3 500GB's and a 400GB, a DVDRW, and a bay reservoir, with the pump underneath them. If you got a different reservoir, that opens up more room there if you need it.
For wire management, you might want to drill some holes in the back, but you can't see them from the outside, especially once everything is put in.
So basically, it's doable, but I will admit, it's pretty tight, especially since video cards are so long these days. A bigger case will definitely make it much easier.
Oh, and my radiator fans run at medium, and the HD fan is on low, and temps are great.