RAM Disks and RAM Speed.

If I were to set up a 4GB RAM disk to put the programs I use most on it (Spotify, Skype, KVIRC, that kind of thing), would I see a large difference in speed between 1333MHz and 1600MHz on my RAM?

Also, would it be worth picking up, say, two more 4GB RAM sticks and making myself a 12GB RAMdisk (or some amount - maybe 2x8GB), rather than an SSD? I rarely ever reboot my computer, so boot times aren't a problem, and I really only need 10GB~ or so.

I'd have games like TF2, where load speed can matter, and my everyday programs on it - I wouldn't need more than one or two games on it, and everything else is small.

You probably won't see much of a difference. RAM will be much faster than any disk, but faster RAM likely won't be noticeably faster than slower RAM - there are other factors that will cause a bottleneck, since just about any speed of RAM will be 'fast enough' for a RAM disk.

Keep in mind that everytime you reboot you'll wipe the RAM disk unless you have some kind of copy-to-disk mechanism in place. For a 10GB disk that means 10GB of copying when you start or shutdown.

I don't think it's worth the hassle, personally. I've messed around with it before. Probably best to get an SSD if you don't have one already.

I reboot maybe once a week. I can live to do that overnight. I'll think about it.

I have 16gb of mushkin 1600mhz 7-7-7-24 on my i7 main rig. I usually run a 8gb disk for chrome cache, temporary files, and occasionally for video editing. Crystaldiskmark scores for this disk is ~9000mb/s read/writes.
I have 6gb of Samsung 1333mhz 9-9-9-24 in my i7 laptop. I regularly have a 2gb disk on this system for chrome cache and temporary files.
Crystaldiskmark scores are ~3500mb/s reads and ~4200mb/s writes.
My patriot wildfire ssd has Abt 500mb/s read and 420mb/s writes.
I can honestly never notice any difference between any of them, even when I try. So I recommend getting 16gb of whatever fits your budget best. the performance will be there no matter.