Nope, won't work. I checked Biostar's website for that motherboard and there are no AM3+ CPUs found in the compatibility list. And if you're going to upgrade to an AM3+ board realize that this community's experience has found that there are a very limited number of motherboards that will truly stand up well to the heat and power draw produced by the 8 core FX CPUs. Expect to pay $180-$225 for a capable board, especially if you will be overclocking.