Lose the ability to gain anymore? Well, if you mean topping out the processor, which means that it's been overclocked to it's highest stable speed, it totally depends on the chip. I'm and AMD user. I run my Duron 1.0Ghz Morgan at 10.5 x 114. That gives me 1197Mhz and my Vcore has been upped. In essence, unless I do alot of cooling and bring up the Vcore more, which makes the CPU really hot, I'm topped out, or caped, at 1197Mhz.
Other Durons, if you check the CPU database. have been overclocked way more. A chip won't lose it's ability to overclock, but it will more than likely fry when it gets to hot. It's like 80*C on an AMD for max, but the more you overclock and you bring up the speed, the hotter things are gonna get, so stability drops. Hope this helped you.