I would advise agains it.
You can VERY easily BLOW A FAN HEADER on a motherboard by overloading it .... (just ask delta fan owners)
Having 3 fans can very well do that, how may amp/or watts do the fans you have run at?
And if you are looking for RPM speed, 1 header cant read 3 fans...
So it would be the safest to run the 3 fans (could leave one) from a 4 pin Molex connector