I would imagine so, pretty sure the 6800 uses the same hole pattern as the FX series cards so the only posible issue I could think of would be if it would clear the ramsinks, however they look to be at most no taller than the 5900 ramsinks and the maze 4 block clears though with 1/2" ID 3/4" OD tubing (just barly though), also in case you're interested danger den is making a new block specificly for the 6800 that water cools both the GPU and the ram, not sure what the price will be but their site says it will go on sale later this month.