Like ehume, I think the TY-14x fans are fantastic, no pun.
I'm running TY-140 fans in my old Define R2. I had to modify the front to accept 140mm fans but end result is a very quiet case with great airflow.
I know a few people who modified TY-140, TY-147 or TY-147A fan for use in Define R4 with great results.
Like ATMINSIDE, I believe the use of good fans using CPU and GPU temps to regulate their speed so they cycle with CPU & GPU fans to supply smooth airflow is the best.
I'm running TY-140 fans in my old Define R2. I had to modify the front to accept 140mm fans but end result is a very quiet case with great airflow.
I know a few people who modified TY-140, TY-147 or TY-147A fan for use in Define R4 with great results.
Like ATMINSIDE, I believe the use of good fans using CPU and GPU temps to regulate their speed so they cycle with CPU & GPU fans to supply smooth airflow is the best.