U.2 has it's own ref clock pinouts, which m.2 doesn't, removing that requirement from the board makes it theoretically twice as fast. Intel's NVMe SSD 750 pci-e card HD had one other option, the SFF-8639 (small form factor) which is now called u.2.
"With prices dropping, does anyone have, or considered, using two NVMEs or two SSDs? Or one NVME and one SSD? "
I plan on using 2 nvme's in raid1 (mirror) via one pci-e 3x4 card, as boot and vm's on a nas. There are 2 std m.2 slots on the nas board along with 4 std hd slots. I will probably put a wireless AP in the other pci-e slot and IF I ever go 10GbE, I'll replace the pci-e nvme raid1 card with the pci-e 10GbE card and then use the 2 m.2 std slots instead. Probably won't make that big of a difference in speed but I've been dying to run nvme's anyway. I'll also put my 2 wd reds in raid 1 as well. Backups will consist of snapshots to the raid1 reds.