depends on the board but since to use the next fsb ie 400mhz/1600, that was on higher end chipsets for the last extreme core 2 intel released. he could pad 1333 to 1600, im sure my table i put together is listed in my thread from ages ago. there might still be the article that was on the ocf back then as well i just dont know if 1600mhz pad settings were listed.
i think he would get a higher clock speed using a Q6600 GO 1066->1333 vs Q8200 1333->1600(if its even possible because of a chipset limitation or so i think). i never messed with lower end boards so yes 1333 to 1600mhz pad mod is a 50/50 shot at best. a pad wont fry the board, worst case it just wont boot, this assumes you double check which pads you doing. since the bsel mod setting is 3 pads on the lga775 to tell the motherboard what fsb setting to use on boot up. now vid pad modding, i think there are six but that is for voltage to feed to the cpu.