Undoubtedly, but the obstruction would be nearly identical in all three scenarios
The issue is that filter obstruction can completely turn around the positive pressure build into a negative pressure build. The fact that you get the exact same results (dust buildup in front of the PCI slot unfiltered openings) for your 3 setups is a clear indication of that.
It doesn't take a lot of obstruction to reduce a fan CFM to a tiny fraction of its nominal value. In fact, when designing for positive pressure, it is quite important to account for the flow reduction due to the air filter. A 100µ dust filter put right on front of a fan reduce the nominal CFM by 20-30%, in a best case scenario and when the filter is perfectly clean. Additional obstruction (like the front case mesh) further reduce fans air flow.
All it take to turn your positive pressure setup into a negative pressure setup is for the 3 intake fans to generate less than 33.3% of their nominal CFM, since you have a 3:1 intake:exhaust ratio.
As you can plainly see, none of the filters were 100% obstructed as you are betting.
What this picture is telling me is that there was a ton of dust on the filter, but it fell off when you opened the case.
My take on this is that the dust you're using is relatively uniform, dry and clean and doesn't stick much to the filters.
In a real world usage, dust is quite greasy, sticky and composed of a greater diversity of fibers. From my own experience, "normal" dust buildup on an air filter doesn't fall off easily.
In fact, I could argue that the differences between "real world" dust and what you're using already make this kind of test quite questionable in the first place.
Long exposure to a low concentration, high diversity dust can't reliably translate into short exposure, high concentration, low diversity dust.
First, this change how the filters perform, second this changes how much dust will settle and stick to surfaces.
The fact that you're actively ventilating the test chamber with an air compressor also likely cause quick to settle heavy particules to be supended in the air in "unnatural" concentrations.
But in any case, my point is that by ignoring that "are dust filters obstructed" variable, your test setup can hardly be used to prove anything. Not making my own test doesn't change the fact that your test has an obvious flaw...
You are way too confident in your conclusions. As others have pointed out, dust prevention through positive pressure filtered intakes is an industry standard.
All industrial electrical/electronics cabinets are designed that way, and it's the basic principle used to design cleanrooms, the physics behind that concept are solid and this has been experimentally validated for decades.
If a specific positive pressure design doesn't work as expected as far as dust prevention is concerned, it's because something is wrong either in the design, or in the usage.
As you mentioned, your 50h test simulate a multi-year exposure to an extremely harsh environment. For it to be representative of a real-world usage, you would need to replicate the real-world usage : filters must be cleaned regularly, before they become significantly obstructed.
My take on a proper test would be to run that test in cycles.
First, you need to determine after how much time the filters are clogged. You could do a test run, checking the filters at regular interval. Also, this is where monitoring system thermals would be useful, as a degradation would be an indication of significant airflow obstruction. A setup with a passively cooled (just a big tower radiator, no fan attached) low-end (~30W TDP) CPU would be extremely sensitive to case internal air flow, that would be a good way to get useful results. A simple test to validate if the setup is still positive pressure would be to put some smoke (incense, electronic cigarette...) in front of the PCI openings to see if it gets sucked in or not.
Once you have a decent estimate of "filter clogging time", run the test for that time, stop it, clean the filters, and repeat. Stop repeating when you have enough dust buildup inside one of the test setups to make a meaningful comparison.