Hi Mike;
When I saw you first design, I immediately wondered why you chose an "end-to-end" flow approach as opposed to a "center- outward" design like most of the mainstream blocks use nowadays. Of course, it would be hard to not use an end-to-end flow with your fin design. From my tinkering with different blocks, the biggest revelation for me has been the fact that regardless of the block geometry, if you have a decent pump and radiator, just about any block works well. Certainly better than most air cooling solutions.
As to base thickness, I believe with an end-to-end design like yours, start with something on the order of 1/4" (6mm) or so. Like the last fellow who replied to your thread, you can always mill it down further. I personally like your idea of thinner right above the CPU. Keep in mind that the best performing water block I have tested to date, had a thickness of only .050" (1.25mm) but that was a spiraling center-outward design.
There is beginning to be a split in water block design, whether informed people want to acknowledge it or not. There are water blocks that excell at cooling straight CPUs without the use of a peltier device and blocks that perform ever so slightly less with a straight CPU, but do better with a peltier device. End-to-end designs like yours seem to fall into the second category. Thin base spiral blocks tend to fall into the first category. That is my gut feeling and my gut rarely lets me down.
John