I can see water cooling the CPU and maybe the vid card GPU, but I doubt the motherboard needs water cooled. Kind of mega overkill. But, you should at least put a heatsink and fan on the motherboard's northbridge chip though. Most already have a "greenie" sink, if so, just install a 40mm fan onto the sink using the right size screws. Also, a Blue Orb works good as a chipset cooler too. If you're concerned with the RAM, just position a fan to blow across the modules, but I doubt it'll be a problem if you already have good case cooling.