Have you checked RAM. I've had random scenarios where I thought a keyboard, or a mouse has gone bad, and a stick of ram was bad or loose in each occasion. Just a suggestion.
My first thought was instability of the overclock, but you sound like you've got it pretty stable. It might help to up the voltage, but will raise your Temps as well.
+1 to Lochekey and reverting to stock to see if it fixes the issue. If reverting to stock doesn't fix the issue then you know your overclock isn't to blame
What about a different keyboard and mouse? Drivers and overclock are ruled out. Time to check hardware.
Edit:The only other option that I know of is a fresh install of Windows -- or maybe reverting to a restore point before the problem -- maybe someone else will chime in though
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