It means good luck trying
... usually specs are lower than the maximum clock as it depends on too many variables to guarantee that. Try to play with various settings and maybe it will work higher. On AMD about 4400 is max with 4 memory modules, on Intel, the memory controller is stronger so should OC higher but some other things may cause stability issues. For example, 2/4 slots OC better while 1/3 worse.
Btw. don't focus on SA too much. More important is IO 2 for a higher memory clock. You can leave SA at ~1.30-1.35V but push IO 2 to 1.4-1.5V if you are stuck at some frequency. Once you stabilize everything, try to drop voltages as both SA and IO are heating up the CPU. Still safe but no reason to keep it too high when it's not required.
I'm not sure if you have signal quality reading in BIOS. I have it on Z590I Unify and it was on other Unify boards. It suggests which memory stick may cause instability. I can't check where it was right now but maybe you find it.