Desktop and server chips aren't all that different anymore. But you will still pay a premium for the server version. As a person mentioned before, ECC ram compatibility is one of the main added features. But the ECC ram is also going to cost more. I don't know about AMD but the Xeon versions of chips have extra PCI lanes. So say you don't want to need a few more PCI lanes than the LGA 1155 boards have but you don't want to go all the way to an LGA 2011 build, you can instead get a 1155 Xeon and matching board.
As for that 16 core behemoth you're considering, you gonna have to give more details on what you plan to do. Unless you are running a true server, i dunno how you're gonna use all 16 cores. There are the SB-E chips with 6physical cores and 12 logical.
To my knowledge the are not always better for OCing (but i could be wrong). Yes they run at lower voltages and consume less power, but they also cannot tolerate as high a voltage and when you increase the clock you need more power...
so, what do you plan to do with this machine?