I'm using a Nexus 201 and the knobs protrude about 9/16" from the faceplate. The door on the Coolermaster looks pretty deep in the photo, but I have no way of being certain. Doubt if it's a problem. Just FYI the Nexus will adjust from 7v to 12v to alter fan speed, if you need something that will actually turn off fans completely you may want to investigate the Sunbeam unit. Also, make sure you get a newer revision of the Nexus if you decide to get one, as the earlier units appear to have had some problems with a screw that was not properly isolated from the pcb...do search on these forums for "Vantec Nexus Death/ Destruction Thread". My Nexus is a later revision that does not have this issue and it works flawlessly (so far!).