Look at the back plate:
GTX295. With other graphics cards, if you switch to a single slot cooler, you can remove or replace the back plate with a single slot version since the connectors are on the side with the board. Here, they add an HDMI connector and place the DVI connectors on the second slot side of the black plate. This is going to make it impossible to do SLI and run a sound card or any other card between the graphics cards. Like I said, I surely hope this doesn't continue with the 300 series. Some of us actually use the other slots on the motherboard. This seems to be the nVidia reference design. All of the 295 cards have this issue.