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Is it OK to use 1 x 8GB RAM stick in a Dual Channel (4 slots) ?

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I'm not sure exactly how new controllers are managing data right now. I can only check performance on Z97 or A88X when I find 3 or more similar sticks. Recently I had to sell some RAM so it will be hard with single sided modules for comparison.
 
You can check via performance, however, I believe you would have to fill the dual channel capacity and run into the single stick before you see any performance losses.
 
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