I don't generally because when I'm playing a game that's the last thing I could care about...with a few exceptions, one being Morrowind. I turn it on when I play that because your outside for most of the game, and the depth blur of the textures is greatly improved. It's just personal preference, really. I hardly ever play with AA on...too much of a performance hit on my machine for me, and I could care less about jaggies...