Sansa e260?

Is it possible to run a line from docking station which has line out to a computer
line in to run through my 5.1 system?

you could try it! i can plug my sansa into my home stero line in and play it like that. Its taken me so long to get this ------ up supreme FX II sound card to work i don't want to unplug anything. lol

Should be fine.