part of what you have to think about is heatsink design at the same time. One of the biggest problems with air cooling is that air currents develop that skim the surfaces and create drag and pockets of air that aren't really getting moved. The higher the airflow the more likely you are to encounter this effect. A perfect example of this is Noctua's nh d14, its extremely optimised for low air flow. Throw more air flow at it and you really dont really get any increase in performance out of it.
Other thing you need to think about as you increase airflow is how much more often your gonna need to clean your setup if the air is filtered, or clean your filters if it is . Throw a 252 cfm fan at a heatsink and it will packup with dust faster, thats just the way it works.