to a degree some video card apps use it. I know when I first loaded one of the AMD 13 series drivers on a new install it kept telling me CCC couldn't run without net framework 4.0 once it installed thru updates I no longer got the message. So you never know what exactly uses the net framework unless you dig in to it deeper.
This is the only thing I personally know about I'm sure there are a ton of other things that use net framework
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