I've had a machine fail Prime95 after 22 hours. I lowered the memory clock a bit and then it was able to pass 36 hours. Usually I wouldn't really test it that long, but this was a machine that I put together for a friend so I wanted to make certain that it was 100% stable.
BTW, my primary box can pass prime no problem with the memory timings set as aggressively as possible, and the memory voltage at 2.85v. It crashes during the cpu tests in 3DMark03 if I leave it like that though. Maybe the 3DMark03 test is actually more intense than prime95?