The latency in the drive will far exceed any latency in the bus or controller. As for the speed difference, it depends on which drives are compared. Generally, seek and access times are slightly lower for the 10K SCSI than the 10K SATA drives, but not greatly noticeable in the real world. SATA is much cheaper than SCSI, especially when considering RAID options. SCSI has some other benefits in it's protocols. As far as sheer speed, a pair(or more) of 15K SCSI in RAID-0 on a good controller on at least a 64/66 PCI bus will probably be as fast as you'll be able to get at home, but you'll be broke and in debt. Personally, I prefer SCSI, but for most people SATA will be more than fast enough.