I can give you a definite maybe. Motherboards are sensitive electronic devices, and can be damaged by many things. In a no boot situation, you have to try lots of combinations to be sure that the motherboard is actually the faulty component (strip it down to just the board, CPU, one stick of memory, then swap all of those components with known good ones). Handling a bare motherboard is always risky; storing it without putting it into an anti static bag makes ESD damage likely. But even then it isn't a sure thing, and ESD isn't always fatal. Most of the time it's subtle, and can make components unreliable.
Last Fall I was given a computer to repair by a relative. He included an old Abit NF7 motherboard, and an Nvidia 6800 AGP card in a box without mentioning them. I guess he thought I might be able to use them (and he was right, they are in a computer at work now). They weren't in anti static bags, so I was a pretty dubious about them. But I put them in a case, and they fired right up.
