The number of physical modules doesn't matter, what does matter is the number of ranks on a channel. The modules mentioned I believe are B-die so single rank at 8GB modules. I have no experience with 16GB sticks, would they be dual rank? If so, running 4x8 would be no different from running 2x16. What difference does rank have? In synthetic tests, having 2R per channel give slightly more bandwidth at slightly more latency compared to 1R per channel at otherwise same settings. I've seen bigger throughput differences running 2R per channel with Prime95 like workloads which are heavily ram bandwidth dependent. If I had a choice, I'd rather run 2R per channel than 1R, but that suits my workloads. If you're purely overclocking for speed, 1R per channel is the way to go.