I could barely get past 3600 MHz on anything setting than performance. When I set it to performance I could hit 3866 MHz with no issues (17-18-18) but the voltage was too close to 1.55v so I backed it down to 3733 MHz @15-16-16 and it's been solid there ever since.
edit: I learned a lot OC'ing my RAM. I'm far from a memory guru (That would be Woomack), but my thread is here https://www.overclockers.com/forums/showthread.php/787371-3866-MHz-Too-much-is-enough and everything is pretty well documented for my Gigabyte/Z170 Gaming 7 set up.
Based on that mobo's manual, the 'installing memory' section, seems there is no slot preference for 2 stick-configs. Which describes a T-topology, so should expect to reach highest memory speeds when using 4 stick.