Hopefully this is of some use...
What exactly is the majority use for the system? eg is it gamedev eg in unreal, or is it modelling etc.
And are we just talking gamedev asset creation or are you doing cad/architectural visualisation work?
Depending on your answers to these, the advice would vary a lot.
For baking for weeks you are going to want water cooling and I would say go AIO - going air the heat+noise will drive you insane for long bakes.
Regarding gamedev yes, geforce is better than quadro, but if doing any cad/arch-vis, going quadro will give you faster workflow due to tuned drivers for those kind of tasks - eg high antialiasing etc
If you really will be lugging the thing round PAX etc, then whatever you build will all weigh relatively the same.
Are you buying this yourself as an indie, or are you being provided the equipment by your employer?
If indie I say look at workstations such as recent hp z820 z840, would allow you to max out many aspects and they can come with 2 cpus and aio watercooling.
Can take lots of ram, could even have ramdisk for compiling (beats ANY ssd) regarding speed.