The mounting screws or at least the hold-down ears on the Antec 620 would never hold up to the pressure I put on my water blocks. They just don't have enough beef honestly.
You could certainly put the pea sized blob of heat sink compound on the cpu and then position quiet accurately the block itself and knowing the back of my mobo has a spacer to keep the board from bending, i apply pressure by hand to the block (real pressure) and then remove and look at the contact pattern. If not good contact patch then you have found A problem. IF the contact now looks good then you can clean and REapply the pea sized blob on cpu and make sure you hold down on cpu the ENTIRE time you tigthten the hold-down screws and you will have more clamping pressure than just sitting the block up there and tightening the hold-down screws.
There are many things that an individual can do on his own that you will find work for you. You being the operative word here. When trying to 'teach', there is a prescribed method that most originally adhere to.
Like when I begin to use a new cpu on a block I have had for years, I know what the contact patch should look like, so I press it down by hand really hard. Then I look at the patch showing on the new unknown cpu. If okay, I clean the block and add just a half-sized pea blob of heat sink compound to the cpu and mount away. I don't get air most likely due the compound I use and it is n0t AS5 since I hate it for being capacitive at least. But if you learn to do it 'by the book', over time you can learn the working shortcuts.
I used to mount a cpu at least 7 to 10 times a week. I did not have time for a 200 hour burn-in of AS5. I learned a trick around burn-in times. Over the course of mounting so many cpus over a 4 year period, I found my own 'working' methods and had plenty of temp baselines to check out my mounting procedure from each cpu change.
Everybody hates mounting cpus. I do too. But having to do so and so much, got me better suited to do the job and do it where the mounting was not an issue.
RGone...