Whatever your cpu, HDD, RAM and PCI cards, etc will allow you to. The board itseld can go as high as 280, but I doubt you will ever come close to that... I had it running 179 the other day on my pc (multiplier of 10x) but the system was unstable and crashed.
All setups are different... you never quite know what a system will do until you start changing settings... just be carefull and go slow... you don't want to have to reinstall windows :< }((
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