I know, I know, I'm resurrecting a necro-thread, but I've spent WEEKS researching this problem recently and I've discovered a solution that isn't covered in any of the forums I've visited. I'm posting this here because this thread comes up a lot when searching for the symptoms.
For reference, I'm running an FX9590 on my ASUS Sabertooth 990fx rv2.0, with 32gb of DDR1866 (Dominator) RAM, an nVidia 1070, and a 1080i water-cooler, plus many case fans.
Temperatures were stable throughout, no OC on BIOS, CAS timings and voltages set manually for both DIMMs and CPUs (checked with manufacturers specs etc). PC locking up after less than 2 minutes of Windows Desktop operations. Occasional complete lockdown of the system requiring a hard, cold boot (remove power, deplete capacitors). Red CPU_LED and/or DIMM_LED continuously preventing POST.
In windows, CPUID was showing spikes in the CPU, with a baseline of around 4.7, jumping to 5.2, despite turning off any CPU overclocking in UEFI.
SOLUTION: Set CAS timings and voltages correctly for CPU and DIMMs (as I already had, above) and then, in AI Tweaker, DIGI+ power control, disable both CPU power phase (set to default, do not set to optimized) and VRM Spread Spectrum, which both appear to be set to non-default by default!
Having done this, my system is now rock-solid once again, memory running at 1866 and CPU at 4.7, temps are ok, GPU is hammering along.
Hope you found this, and hope it helps!